Promoting Excellence : Treatment Protocol for Uremic Neuropathy in ESRD

Renal Palliative Care Initiative: Treatment Protocol for Uremic Neuropathy in ESRD

This treatment protocol was created to address and manage occurrence of uremic neuropathy in patients with end stage renal disease.

Clinical Care Tools - Symptom Management

Renal Palliative Care Initiative
Baystate Medical Center
759 Chestnut Street S2669
Springfield, MA 01199

Michael Germain, M.D.
[email protected]

How the grantee used this instrument:
This protocol was made available at the clinics and renal unit nursing stations.

esrd, end stage renal disease, uremic neuropathy, dialysis, kidney disease, symptom assessment

To use this tool:
You may print and copy this tool for your own use from this site. Please credit source.


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  2. Walker, S., Fine, A., & Kryger, M.H. "Sleep complaints are common in a dialysis unit." American Journal of Kidney Diseases, 1995; 26:751.
  3. Harris, DC, Chapman, JR, Stewart, KH, et al. "Low dose erythropoietin in maintenance hemodialysis: Improvement in quality of life and reduction in true cost of hemodialysis." Australian & New Zealand Journal of Medicine, 1991; 21:693.
  4. Roger, SD, Harris, DCH, & Stewart, JH. "Possible relation between restless legs and anaemia in renal dialysis patients." Lancet, 337: 1551.
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  6. Collado-Seidel, V, Kohnen, R, Samtleben, W, et al. "Clinical and biochemical findings in uremic patients with and without restless legs syndrome." American Journal of Kidney Diseases, 1998; 31:132.
  7. Winkelman, JW, Cherow, GM, & Lazarus, JM. "Restless legs syndrome in end-stage renal disease." American Journal of Kidney Diseases, 1996; 28: 372.
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  9. Schenck, CH, Mahowald, MW. "Long-term, nightly benzodiazepine treatment of injurious parasomnias and other disorders of disrupted nocturnal sleep in 170 adults." American Journal of Medicine,1996; 100:333
  10. Allen, RP, & Earley, CJ, "Augmentation of the restless lege syndrome with carbidopa/levodopa." Journal of Sleep Research, 1996; 19: 205.
  11. Von Scheele, C, Kempe, V. "Long-term effect of dopaminergic drugs in restless legs: A 2-year follow-up." Archives of Neurology, 1990; 47:1223.
  12. Silber, MH, Shepart, JW Jr, Wisbey, JA. "Pergolide in the management of restless legs syndrome: An extended study." Journal of Sleep Research, 1997; 20:878.
  13. Thorp, ML, Morris, CD, Bagby, SP. "A crossover study of gabapentim in treatment of restless legs syndrome among hemodialysis patients." American Journal of Kidney Diseases, 2001;38:104.
  14. Wagner, ML, Walters, AS, Coleman, "Randomized, double-blind, placebo-controlled study of clonidine in restless legs syndrome." 1996; 19:52.
  15. Walters, AS, Wagner, ML, Hening, WA, et al. "Successful treatment of the idiopathic restless legs syndrome in a randomized double-blind trial of oxycodone versus placebo." Journal of Sleep Research, 1993; 16:327.

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Posted April 2004

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